Here you can find the updated list of OUR peer reviewed publications


Pouvreau B, Fenske R, Ivanova A, Murcha MW, Mylne JS. An interstitial peptide is readily processed from within seed proteins. Plant Sci. 2019 Aug;285:175-183.



Kmiec B, Branca RMM, Berkowitz O, Li L, Wang Y, Murcha MW, Whelan J, Lehtiö J,Glaser E, Teixeira PF. Accumulation of endogenous peptides triggers a pathogen stress response in Arabidopsis thaliana. Plant J. 2018 Nov;96(4):705-715.

Ghifari AS, Gill-Hille M, Murcha MW. Plant mitochondrial protein import: the ins and outs. Biochem J. 2018 Jul 17;475(13):2191-2208.

Belt K, Van Aken O, Murcha M, Millar AH, Huang S. An Assembly Factor Promotes Assembly of Flavinated SDH1 into the Succinate Dehydrogenase Complex. Plant Physiol. 2018 Aug;177(4):1439-1452.

Corral MG, Haywood J, Stehl LH, Stubbs KA, Murcha MW, Mylne JS. Targeting plant DIHYDROFOLATE REDUCTASE with antifolates and mechanisms for genetic resistance. Plant J. 2018 Jun 7.

Lyu W, Selinski J, Li L, Day DA, Murcha MW, Whelan J, Wang Y. Isolation and Respiratory Measurements of Mitochondria from Arabidopsis thaliana. J Vis Exp. 2018 Jan 5;(131).

Kmiec B, Branca RMM, Murcha MW, Lehtiö J, Glaser E, Teixeira PF. A Common Peptidolytic Mechanism for Targeting Peptide Degradation in Mitochondria and Chloroplasts. Mol Plant. 2018 Feb 5;11(2):342-345.

Opalińska M, Parys K, Murcha MW, Jańska H. The plant i-AAA protease controls the turnover of an essential mitochondrial protein import component. J Cell Sci. 2018 Jan 29;131(2). pii: jcs200733.


Teixeira, P.F., Kmiec, B., Branca, R.M., Murcha, M.W., Byzia, A., Ivanova, A., Whelan, J., Drag, M., Lehtio, J. and Glaser, E. (2017) A multi-step peptidolytic cascade for amino acid recovery in chloroplasts. Nat Chem Biol, 13, 15-7.



Wang, Y., Lyu, W., Berkowitz, O., Radomiljac, J.D., Law, S.R., Murcha, M.W., Carrie, C., Teixeira, P.F., Kmiec, B., Duncan, O., Van Aken, O., Narsai, R., Glaser, E., Huang, S., Roessner, U., Millar, A.H. and Whelan, J. (2016) Inactivation of Mitochondrial Complex I Induces the Expression of a Twin Cysteine Protein that Targets and Affects Cytosolic, Chloroplastidic and Mitochondrial Function. Mol Plant, 9, 696-710.

Murcha, M.W., Kubiszewski-Jakubiak, S., Teixeira, P.F., Gugel, I.L., Kmiec, B., Narsai, R., Ivanova, A., Megel, C., Schock, A., Kraus, S., Berkowitz, O., Glaser, E., Philippar, K., Marechal-Drouard, L., Soll, J. and Whelan, J. (2016) Plant-Specific Preprotein and Amino Acid Transporter Proteins Are Required for tRNA Import into Mitochondria. Plant Physiol, 172, 2471-90.

Lee CP, Maksaev G, Jensen GS, Murcha MW, Wilson ME, Fricker M, Hell R, Haswell ES, Millar AH, Sweetlove L. MSL1 is a mechanosensitive ion channel that dissipates mitochondrial membrane potential and maintains redox homeostasis inmitochondria during abiotic stress. Plant J. 2016 Aug 9. doi: 10.1111/tpj.13301. 

Kmiec B, Teixeira PF, Murcha MW, Glaser E. Divergent evolution of the M3A Divergent evolution of the M3A family of metallopeptidases in plants. Physiol Plant. 2016 Apr 21

Wang Y, Lyu W, Berkowitz O, Radomiljac JD, Law SR, Murcha MW, Carrie C, Teixeira PF, Kmiec B, Duncan O, Van Aken O, Narsai R, Glaser E, Huang S, Roessner U, Millar AH, Whelan J.

Inactivation of mitochondrial complex I induces the expression of a twin-cysteine protein that targets and affects cytosolic, chloroplastidic and mitochondrial function. Mol Plant. 2016 Jan 29.


Law YS, Zhang R, Guan X, Cheng S, Sun F, Duncan O, Murcha M, Whelan J, Lim BL.
Phosphorylation and Dephosphorylation of the Presequence of pMORF3 During Import
into Mitochondria from Arabidopsis thaliana. Plant Physiol. 2015 Aug 24.

Duncan O, Carrie C, Wang Y, Murcha MW. In vitro and in vivo protein uptake studies in plant mitochondria.

Methods Mol Biol. 2015;1305:61-81.

Murcha MW, Whelan J. Isolation of Intact Mitochondria from the Model Plant Species Arabidopsis thaliana and Oryza sativa. Methods Mol Biol. 2015;1305:1-12. 
Murcha MW, Narsai R, Devenish J, Kubiszewski-Jakubiak S, Whelan J. MPIC: a mitochondrial protein import components database for plant and non-plant species. Plant Cell Physiol. 2015 Jan;56(1)


Murcha MW, Kmiec B, Kubiszewski-Jakubiak S, Teixeira PF, Glaser E, Whelan J

Protein import into plant mitochondria: signals, machinery, processing, and

J Exp Bot. 2014 Dec;65(22):6301-35.

Wang Y, Law SR, Ivanova A, van Aken O, Kubiszewski-Jakubiak S, Uggalla V, van
der Merwe M, Duncan O, Narsai R, Whelan J, Murcha MW.

The mitochondrial protein import component, TRANSLOCASE OF THE INNER MEMBRANE17-1, plays a role in defining the timing of germination in Arabidopsis.

Plant Physiol. 2014 Nov;166(3):1420-35.

Zhang B, Van Aken O, Thatcher L, De Clercq I, Duncan O, Law SR, Murcha MW, van
der Merwe M, Seifi HS, Carrie C, Cazzonelli C, Radomiljac J, Höfte M, Singh KB,
Van Breusegem F, Whelan J.

The mitochondrial outer membrane AAA ATPase AtOM66 affects cell death and pathogen resistance in Arabidopsis thaliana.

Plant J. 2014 Nov;80(4):709-27

Murcha MW, Kubiszewski-Jakubiak S, Wang Y, Whelan J.

Evidence for interactions between the mitochondrial import apparatus and respiratory chain complexes via
Tim21-like proteins in Arabidopsis.

Front Plant Sci. 2014 Mar 11;5:82. doi:

Kmiec B, Teixeira PF, Berntsson RP, Murcha MW, Branca RM, Radomiljac JD, Regberg J, Svensson LM, Bakali A, Langel U, Lehtiö J, Whelan J, Stenmark P, Glaser E.

Organellar oligopeptidase (OOP) provides a complementary pathway for targeting peptide degradation in mitochondria and chloroplasts.

Proc Natl Acad Sci U S A 2013 Oct 1;110(40):E3761-9.


Murcha MW, Wang Y, Narsai R, Whelan J.

The plant mitochondrial protein import apparatus - The differences make it interesting.

Biochim Biophys Acta 2013 Sep 28. pii: S0304-4165(13)00411-X


De Clercq I, Vermeirssen V, Van Aken O, Vandepoele K, Murcha MW, Law SR, Inzé A, Ng S, Ivanova A, Rombaut D, van de Cotte B, Jaspers P, Van de Peer Y, Kangasjärvi J, Whelan J, Van Breusegem F.

The membrane-bound NAC transcription factor ANAC013 functions in mitochondrial retrograde regulation of the oxidative stress response in Arabidopsis.

Plant Cell 2013 Sep;25(9):3472-90


Xu L, Law SR, Murcha MW, Whelan J, Carrie C.

The dual targeting ability of type II NAD(P)H dehydrogenases arose early in land plant evolution.

BMC Plant Biol. 2013 Jul 10;13:100


Xu J, Yang J, Wu Z, Liu H, Huang F, Wu Y, Carrie C, Narsai R, Murcha M, Whelan J, Wu P.

Identification of a dual-targeted protein belonging to the mitochondrial carrier family that is required for early leaf development in rice.

Plant Physiol. 2013 Apr;161(4):2036-48


Duncan O, Murcha MW, Whelan J.

Unique components of the plant mitochondrial protein import apparatus.

Biochim Biophys Acta. 2013 Feb;1833(2):304-13


Xu L, Carrie C, Law SR, Murcha MW, Whelan J.

Acquisition, conservation, and loss of dual-targeted proteins in land plants.

Plant Physiol. 2013 Feb;161(2):644-62. 2012 Dec 20


Carrie C, Murcha MW, Giraud E, Ng S, Zhang MF, Narsai R, Whelan J.

How do plants make mitochondria?

Planta. 2013 Feb;237(2):429-39


Zhang B, Carrie C, Ivanova A, Narsai R, Murcha MW, Duncan O, Wang Y, Law SR, Albrecht V, Pogson B, Giraud E, Van Aken O, Whelan J.

LETM proteins play a role in the accumulation of mitochondrially encoded proteins in Arabidopsis thaliana and AtLETM2 displays parent of origin effects.

J Biol Chem. 2012 Dec 7;287(50):41757-73


Murcha MW, Wang Y, Whelan J.

A molecular link between mitochondrial preprotein transporters and respiratory chain complexes.

Plant Signal Behav. 2012 Dec;7(12):1594-7


Sun F, Carrie C, Law S, Murcha MW, Zhang R, Law YS, Suen PK, Whelan J, Lim BL.

AtPAP2 is a tail-anchored protein in the outer membrane of chloroplasts and


Plant Signal Behav. 2012 Aug;7(8):927-32


Roston RL, Gao J, Murcha MW, Whelan J, Benning C.

TGD1, -2, and -3 proteins involved in lipid trafficking form ATP-binding cassette (ABC) transporter with multiple substrate-binding proteins.

J Biol Chem 2012 Jun 15;287(25):21406-15.


Wang Y, Carrie C, Giraud E, Elhafez D, Narsai R, Duncan O, Whelan J, Murcha MW.

Dual location of the mitochondrial preprotein transporters B14.7 and Tim23-2 in complex I and the TIM17:23 complex in Arabidopsis links mitochondrial activity and biogenesis.

Plant Cell 2012 Jun;24(6):2675-95


Kühn K, Carrie C, Giraud E, Wang Y, Meyer EH, Narsai R, des Francs-Small CC, Zhang B, Murcha MW, Whelan J.

The RCC1 family protein RUG3 is required for splicing of nad2 and complex I biogenesis in mitochondria of Arabidopsis thaliana.

Plant J 2011 Sep;67(6):1067-80


Giraud E, Ng S, Carrie C, Duncan O, Low J, Lee CP, Van Aken O, Millar AH, Murcha M, Whelan J.

TCP transcription factors link the regulation of genes encoding mitochondrial proteins with the circadian clock in Arabidopsis thaliana.

Plant Cell 2010 Dec;22(12):3921-34


Carrie C, Murcha MW, Whelan J.

An in silico analysis of the mitochondrial protein import apparatus of plants.

BMC Plant Biol 2010 Nov 16;10:249


Carrie C, Giraud E, Duncan O, Xu L, Wang Y, Huang S, Clifton R, Murcha M, Filipovska A, Rackham O, Vrielink A, Whelan J.

Conserved and novel functions for Arabidopsis thaliana MIA40 in assembly of proteins in mitochondria and peroxisomes.

J Biol Chem 2010 Nov 12;285(46):36138-48


Carrie C, Kühn K, Murcha MW, Duncan O, Small ID, O'Toole N, Whelan J.

Approaches to defining dual-targeted proteins in Arabidopsis.

Plant J 2009 Mar;57(6):1128-39


Carrie C, Murcha MW, Kuehn K, Duncan O, Barthet M, Smith PM, Eubel H, Meyer E, Day DA, Millar AH, Whelan J.

Type II NAD(P)H dehydrogenases are targeted to mitochondria and chloroplasts or peroxisomes in Arabidopsis thaliana.

FEBS Lett 2008 Sep 3;582(20):3073-9


Lister R, Carrie C, Duncan O, Ho LH, Howell KA, Murcha MW, Whelan J.

Functional definition of outer membrane proteins involved in preprotein import into mitochondria.

Plant Cell 2007 Nov;19(11):3739-59


Olejnik K, Murcha MW, Whelan J, Kraszewska E.

Cloning and characterization of AtNUDT13, a novel mitochondrial Arabidopsis thaliana Nudix hydrolase specific for long-chain diadenosine polyphosphates.

FEBS J 2007 Sep;274(18):4877-85


Howell KA, Cheng K, Murcha MW, Jenkin LE, Millar AH, Whelan J.

Oxygen initiation of respiration and mitochondrial biogenesis in rice.

J Biol Chem 2007 May 25;282(21):15619-31


Carrie C, Murcha MW, Millar AH, Smith SM, Whelan J.

Nine 3-ketoacyl-CoA thiolases (KATs) and acetoacetyl-CoA thiolases (ACATs) encoded by five genes in Arabidopsis thaliana are targeted either to peroxisomes or cytosol but not to mitochondria.

Plant Mol Biol 2007 Jan;63(1):97-108


Murcha MW, Elhafez D, Lister R, Tonti-Filippini J, Baumgartner M, Philippar K, Carrie C, Mokranjac D, Soll J, Whelan J.

Characterization of the preprotein and amino acid transporter gene family in Arabidopsis.

Plant Physiol 2007 Jan;143(1):199-212


Elhafez D, Murcha MW, Clifton R, Soole KL, Day DA, Whelan J.

Characterization of mitochondrial alternative NAD(P)H dehydrogenases in Arabidopsis: intraorganelle location and expression.

Plant Cell Physiol 2006 Jan;47(1):43-54.


Murcha MW, Millar AH, Whelan J.

The N-terminal cleavable extension of plant carrier proteins is responsible for efficient insertion into the inner mitochondrial membrane.

J Mol Biol 2005 Aug 5;351(1):16-25


Murcha MW, Rudhe C, Elhafez D, Adams KL, Daley DO, Whelan J.

Adaptations required for mitochondrial import following mitochondrial to nucleus gene transfer of ribosomal protein S10.

Plant Physiol 2005 Aug;138(4):2134-44


Murcha MW, Elhafez D, Millar AH, Whelan J.

The C-terminal region of TIM17 links the outer and inner mitochondrial membranes in Arabidopsis and is essential for protein import.

J Biol Chem 2005 Apr 22;280(16):16476-83


Murcha MW, Elhafez D, Millar AH, Whelan J.

The N-terminal extension of plant mitochondrial carrier proteins is removed by two-step processing: the first cleavage is by the mitochondrial processing peptidase.

J Mol Biol 2004 Nov 19;344(2):443-54


Murcha MW, Lister R, Ho AY, Whelan J.

Identification, expression, and import of components 17 and 23 of the inner mitochondrial membrane translocase from Arabidopsis.

Plant Physiol 2003 Apr;131(4):1737-47


Lister R, Murcha MW, Whelan J.

The Mitochondrial Protein Import Machinery of Plants (MPIMP) database.

Nucleic Acids Res 2003 Jan 1;31(1):325-7


Tanudji M, Dessi P, Murcha M, Whelan J.

Protein import into plant mitochondria: precursor proteins differ in ATP and membrane potential requirements.

Plant Mol Biol 2001 Feb;45(3):317-25


Murcha MW, Huang T, Whelan J. Import of precursor proteins into mitochondria

from soybean tissues during development.

FEBS Lett 1999 Dec 24;464(1-2):53-9

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